Lyme Disease Vaccine-various aspects-
While a vaccine for Lyme disease, LYMErix, was once offered, it was discontinued because of low sales, and at present, there is no licensed vaccine for Lyme disease available in the US. Nevertheless, Pfizer and Valneva are working together to create a new vaccine candidate, VLA15, which is now undergoing Phase 3 clinical trials.
Here’s a more detailed look at the current situation regarding Lyme disease vaccines:
Past Lyme Disease Vaccine (LYMErix):
Approval and Discontinuation:
In 1998, the FDA granted approval to LYMErix, a recombinant outer surface protein A (OspA) vaccine, intended to prevent Lyme disease in individuals aged 15-70 years.
Efficacy:
LYMErix showed a protective efficacy of 76% against confirmed cases of Lyme disease in prelicensure clinical trials.
Reason for Discontinuation:
The manufacturer voluntarily ceased production in February 2002 due to low sales.
If Any Patient of ENT Requires Any Surgery, Opd Consultation Or Online Consultation In Clinic of ENT Specialist Doctor Dr. Sagar Rajkuwar ,He May Contact Him At The Following Address-
Prabha ENT Clinic, Plot no 345,Saigram Colony, Opposite Indoline Furniture Ambad Link Road ,Ambad ,1 km From Pathardi Phata Nashik ,422010 ,Maharashtra, India-Dr. Sagar Rajkuwar (MS-ENT), Cell No- 7387590194, 9892596635
Current Lyme Disease Vaccine Development (VLA15)
Collaboration:
Pfizer and Valneva have joined forces to co-develop and market a vaccine candidate for Lyme disease, VLA15.
Mechanism of Action:
VLA15 is a multivalent protein subunit vaccine designed to target the outer surface protein A (OspA) produced by the Borrelia bacteria while it is within the tick.
Phase 3 Trial:
Pfizer and Valneva have launched a Phase 3 study of VLA15, referred to as the VALOR trial, which has recruited 9,437 participants aged 5 years and older.
Trial Details:
The VALOR trial is a randomized, observer-blind, placebo-controlled study taking place in regions where Lyme disease is highly endemic across the U. S. , Canada, and Europe.
Expected Data Readout:
The initial data readout for the Phase 3 trial is anticipated by the end of 2025.
Booster Results:
Valneva and Pfizer announced further positive Phase 2 booster results for the Lyme disease vaccine candidate.
A vaccine for Lyme disease is not presently obtainable. The sole vaccine that was formerly sold in the United States, LYMERix®, was withdrawn by the producer in 2002, citing inadequate consumer interest. The defense offered by this vaccine diminishes as time passes.
Description
The Lyme disease vaccine is an active immunizing agent utilized to prevent infection from Lyme disease bacteria. It functions by prompting your body to produce its own defense (antibodies) against the bacteria.
Lyme disease results in rash, fever, weakness, as well as joint and muscle pain. The illness is caused by bacteria transmitted to humans through the bite of infected ticks.
The likelihood of contracting tick-borne infections can be reduced by taking precautions such as wearing long-sleeved shirts and long pants, tucking pants into socks, treating clothing with tick repellent, and inspecting for and removing any attached ticks.
This medication is no longer available for commercial sale.
Before Using
When opting to use a vaccine, the potential risks associated with taking the vaccine must be evaluated against the benefits it will provide. This is a determination that you and your physician will reach together. For this vaccine, the following factors should be taken into account:
Allergies
Inform your doctor if you have ever experienced any unusual or allergic reactions to this medication or any other medications. Additionally, inform your healthcare professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, examine the label or package ingredients thoroughly.
For update on further important health related topics and frequently asked questions on health topics by general population please click on the link given below to join our WhatsApp group –
https://chat.whatsapp.com/Lv3NbcguOBS5ow6X9DpMMA
Pediatric
The Lyme disease vaccine has not been evaluated in individuals younger than 15 years. Its use is not advised in infants and children.
Geriatric
Numerous medications have not been specifically researched in older populations. Consequently, it may not be clear whether they function precisely as they do in younger adults. While there is no specific data comparing the use of the Lyme disease vaccine in the elderly with usage in other age groups, this vaccine is not anticipated to produce different side effects or issues in older adults compared to younger individuals.
Breastfeeding
Research involving women indicates that this medication presents minimal risk to the infant when utilized during breastfeeding.
Drug Interactions
While some medications should not be combined at all, in other instances, two different drugs may be used together even if an interaction could occur. In such situations, your doctor may wish to adjust the dosage, or other precautions may be required. Inform your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medications.
Other Interactions
Certain medications should not be taken at or near mealtime or when consuming certain food types because interactions may happen. The use of alcohol or tobacco in conjunction with specific medications may also lead to interactions. Speak with your healthcare professional regarding the usage of your medication with food, alcohol, or tobacco.
Other Medical Problems
The existence of additional medical issues may influence the administration of the Lyme disease vaccine. Be sure to inform your doctor if you have any other medical conditions.
Proper Use
Dosing
The dosage of this medication will vary for each patient. Adhere to your doctor’s instructions or the guidelines provided on the label. The information below includes just the typical doses of this medication. If your dosage is different, do not modify it unless advised by your doctor.
The quantity of medicine you take is contingent upon the potency of the medication. Additionally, the frequency of doses taken daily, the intervals between doses, and the duration for which you take the medication are determined by the medical condition for which you are using the medication.
This medication is no longer available on the market.
Side Effects
In addition to its beneficial effects, a medication may result in some undesirable effects. Although not every one of these side effects may manifest, if they do occur, they could require medical assistance.
Consult your doctor promptly if any of the following side effects arise:
More common
Numbness
Tingling
Unusual tiredness or weakness
Less common
Bone pain
Chills
Cough
Fever
Muscle aches
Runny or stuffy nose
Shivering
Skin rash, itching, redness, swelling, or other sign of irritation not present prior to vaccination
Sneezing
Sore throat
Sweating
Rare
Difficulty swallowing
Dizziness
Fast heartbeat
Severe headache
Puffiness or swelling around the eyelids
Shortness of breath
Some side effects may appear that typically do not require medical attention. These side effects could diminish as your body acclimates to the medication. Additionally, your healthcare professional may be able to inform you of methods to prevent or alleviate some of these side effects. Consult your healthcare professional if any of the following side effects persist or become bothersome or if you have any inquiries concerning them:
More common
Back pain
Pain in joints and/or muscles
Less common
Depression
Diarrhea
Dizziness
Feeling unusually cold
Other side effects not mentioned may also occur in certain patients. If you observe any other effects, consult your healthcare professional.
FOR INFORMATION IN GREAT DETAIL ON Lyme Disease PL CLICK ON THE LINK GIVEN BELOW-It Is Always Better To View Links From Laptop/Desktop Rather Than Mobile Phone As They May Not Be Seen From Mobile Phone. ,In Case Of Technical Difficulties You Need To Copy Paste This Link In Google Search. In Case If You Are Viewing This Blog From Mobile Phone You Need To Click On The Three Dots On The Right Upper Corner Of Your Mobile Screen And ENABLE DESKTOP VERSION.
FOR INFORMATION IN GREAT DETAIL ON Lyme Disease Treatment PL CLICK ON THE LINK GIVEN BELOW-It Is Always Better To View Links From Laptop/Desktop Rather Than Mobile Phone As They May Not Be Seen From Mobile Phone. ,In Case Of Technical Difficulties You Need To Copy Paste This Link In Google Search. In Case If You Are Viewing This Blog From Mobile Phone You Need To Click On The Three Dots On The Right Upper Corner Of Your Mobile Screen And ENABLE DESKTOP VERSION.
FOR INFORMATION IN GREAT DETAIL ON Lyme Disease Symptoms PL CLICK ON THE LINK GIVEN BELOW-It Is Always Better To View Links From Laptop/Desktop Rather Than Mobile Phone As They May Not Be Seen From Mobile Phone. ,In Case Of Technical Difficulties You Need To Copy Paste This Link In Google Search. In Case If You Are Viewing This Blog From Mobile Phone You Need To Click On The Three Dots On The Right Upper Corner Of Your Mobile Screen And ENABLE DESKTOP VERSION.
FOR INFORMATION IN GREAT DETAIL ON Lyme Disease Causes PL CLICK ON THE LINK GIVEN BELOW-It Is Always Better To View Links From Laptop/Desktop Rather Than Mobile Phone As They May Not Be Seen From Mobile Phone. ,In Case Of Technical Difficulties You Need To Copy Paste This Link In Google Search. In Case If You Are Viewing This Blog From Mobile Phone You Need To Click On The Three Dots On The Right Upper Corner Of Your Mobile Screen And ENABLE DESKTOP VERSION.
If Any Patient of ENT Requires Any Surgery, Opd Consultation Or Online Consultation In Clinic of ENT Specialist Doctor Dr. Sagar Rajkuwar ,He May Contact Him At The Following Address-
Prabha ENT Clinic, Plot no 345,Saigram Colony, Opposite Indoline Furniture Ambad Link Road ,Ambad ,1 km From Pathardi Phata Nashik ,422010 ,Maharashtra, India-Dr. Sagar Rajkuwar (MS-ENT), Cell No- 7387590194, 9892596635
Issued in public interest by –
www.entspecialistinnashik.com
